Support centre

You first complete an online consultation. This helps to determine whether you may be suitable for treatment.

The online consultation asks about your medical history, your previous experiences with weight loss and your goals. It's important to answer everything fully and honestly, so that any treatment supplied is suitable and effective for you.

If you may be eligible after completing the online consultation, you'll be asked to create an account and provide payment details to complete your order. You'll also be asked for identity and weight verification, and to consent to your GP being told about your treatment.

After this, your consultation, information and medical history are reviewed by a qualified clinician from Blueco Healthcare Limited, who may follow up with you directly if they have more questions before approving any treatment for you. The clinician may phone you, or email you from a blueco.care address, before approving any treatment, so please look out for their call or email (and check your spam folder).

As well as the online consultation, we need to verify your identity and current weight. After checkout you upload photo ID, take full-length photos and a photo of you on your scales with the camera in your account (or record one short video instead), and tell us your GP practice. We check these are complete and clear before your consultation goes to the clinician.

A qualified clinician reviews all your details, including your medical history in your Summary Care Record (SCR), and makes the final decision about supplying treatment to you. If necessary, they may contact you directly for more information before they decide. Each month you complete a check-in, which a clinician reviews before your next order.

Treatment is not suitable for everyone. This can be for a variety of reasons, such as certain medical conditions or past medical history, or your current BMI.

In some cases you'll find out after completing the online consultation that you aren't suitable for treatment. In others, a clinician may decide on review that you aren't eligible. If it's decided that treatment isn't suitable for you, you'll receive a full refund.

People already on treatment may at some point no longer be eligible. We monitor this through regular check-ins to make sure you're getting on well with the treatment, but changes in medical conditions, or certain side effects, may mean you need to stop.

If you aren't eligible, please remember that this is for your own health. If you'd still like to explore other options for weight loss, speak to your GP.

Choose "I've taken weight loss treatment before" on our home page, or press Start your consultation and tell us.

If it was with another provider, you start the consultation for people switching provider. After checkout you can upload proof of your previous prescription. If you've had treatment with Happen before, log in to your account to restart.

Yes. It's important that all your healthcare professionals, including your GP, know about any medicines you're taking or have taken recently.

With your consent, the clinician writes to your GP to tell them about your treatment so they can update your health records. This supports continuity of care and helps other professionals, including in an emergency, make fully informed decisions.

If you'd prefer your GP isn't contacted, the clinician will talk through your reasons with you and consider whether they can still prescribe or supply treatment without informing your GP. This is a clinical decision and, in some cases, the clinician may decide they can't proceed without notifying your GP.

You see the price of the treatment and dose you choose before you pay at checkout. A clinician then reviews your consultation. If it's decided that treatment isn't suitable for you, you'll receive a full refund.

Depending on your consultation, a clinician may recommend Mounjaro® (tirzepatide), Wegovy® (semaglutide), Wegovy® (semaglutide) tablets, Foundayo® (orforglipron) tablets or Orlistat 60 mg capsules.

You and your clinician will decide together which treatment, if any, is right for you.

A prescription-only weekly injection. Its active ingredient is tirzepatide.

Average 22.5% weight loss over 72 weeks at 15 mg in people who took it as directed (SURMOUNT-1 trial). Individual results vary.

Jastreboff AM et al. Tirzepatide once weekly for the treatment of obesity. N Engl J Med 2022. doi:10.1056/NEJMoa2206038

A prescription-only weekly injection. Its active ingredient is semaglutide.

Average 16.9% weight loss over 68 weeks at 2.4 mg in people who took it as directed (STEP 1 trial). Individual results vary.

Wilding JPH et al. Once-weekly semaglutide in adults with overweight or obesity. N Engl J Med 2021;384:989–1002. doi:10.1056/NEJMoa2032183

Average 20.7% weight loss over 72 weeks at 7.2 mg in people who took it as directed (STEP UP trial). Individual results vary.

Wharton S et al. Once-weekly semaglutide 7·2 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial. Lancet Diabetes Endocrinol 2025;13(11):949–963. doi:10.1016/S2213-8587(25)00226-8

A prescription-only daily tablet. Its active ingredient is semaglutide.

Average 16.6% weight loss over 64 weeks at 25 mg in people who took it as directed (OASIS 4 trial). Individual results vary.

Wharton S et al. Oral semaglutide at a dose of 25 mg in adults with overweight or obesity. N Engl J Med 2025;393:1077–1087. doi:10.1056/NEJMoa2500969

A prescription-only daily tablet. Its active ingredient is orforglipron.

Average 12.4% weight loss over 72 weeks at 36 mg in people who took it as directed (ATTAIN-1 trial). Individual results vary.

Wharton S et al. N Engl J Med 2025. doi:10.1056/NEJMoa2511774

A capsule taken with meals. It acts in your digestive system to stop some of the fat you eat from being absorbed.

Wegovy and Mounjaro are both weekly injections that help many people lose weight. Orlistat comes as a capsule taken up to three times a day. All three work in different ways.

Wegovy contains semaglutide, which mimics the GLP-1 hormone to help you feel fuller for longer. Mounjaro contains tirzepatide, which acts on both GLP-1 and GIP receptors; this can help manage appetite and support energy storage. Orlistat works by blocking the enzymes in the stomach and intestine that break down dietary fats, which stops about a third of the fat you've eaten from being absorbed into the body.

Mounjaro is prescribed for both weight loss and type 2 diabetes, while Wegovy and Orlistat are used only for weight loss.

The two injectable medicines follow different dosing schedules and are made by different manufacturers: Wegovy by Novo Nordisk and Mounjaro by Eli Lilly. In the UK Orlistat is available in two strengths, 60 mg and 120 mg, but there is no dose escalation: you start and stay on the same dose. Happen only offers the 60 mg dose of Orlistat, which is made by Haleon UK Trading Ltd.

Yes. Switching is possible, and sometimes recommended, if a medicine isn't working well for you. Let the clinician know and they will help decide which is right for you if you're not seeing results or are struggling with side effects.

Some of the medicines work in similar ways and may cause similar side effects, so switching doesn't always mean faster results or fewer side effects.

If you do switch, you'll start from the lowest dose of the new medicine and increase gradually, just as you did at the beginning, where that applies. If your current treatment is working well, the clinician may recommend staying on it to avoid unnecessary changes.

No. Wegovy (semaglutide), Mounjaro (tirzepatide) and Orlistat are not addictive or habit-forming.

Any medicine prescribed through Happen is licensed for use in the UK by the MHRA. A clinician decides whether it is suitable for you.

No. Treatment is only suitable for some people.

The consultation and checks help the clinician decide whether treatment is suitable for you, and monthly check-ins let them keep that under review.

Everyone is different. You complete a check-in each month so a clinician can review how you are getting on.

If you have any concerns, tell us in your check-in or contact our support team. Email [email protected] or call 0333 004 0020 (Monday to Friday, 09:30 to 18:30). We reply to emails on the next working day.

With Wegovy (semaglutide) and Mounjaro (tirzepatide), only if you're already taking that same medicine through another provider and your dose can be verified. For Orlistat, Happen only offers one dose, so there is no escalation.

Wegovy and Mounjaro both follow a gradual dose increase (called titration) to reduce side effects. Starting low and building up gives your body time to adjust. Some people need to increase their dose more slowly than others.

If you're continuing treatment started elsewhere, the clinician will usually support you in picking up from your current dose, provided it's suitable for you and meets our prescribing criteria.

The different dose strengths of Wegovy and Mounjaro are part of a planned, gradual increase to help your body adjust and reduce side effects. This process is called titration.

For Wegovy (semaglutide), the journey starts at 0.25 mg weekly and typically increases every four weeks until reaching the 2.4 mg maintenance dose. The 7.2 mg dose of Wegovy is also available for eligible patients. For Mounjaro (tirzepatide), you start at 2.5 mg and may increase in stages up to 15 mg, though not everyone needs the highest dose: 5 mg, 10 mg and 15 mg are all considered maintenance doses.

These stepped increases aim to give you the best possible results with the fewest side effects. Maintenance doses for Wegovy and Mounjaro are those clinically shown to be the most effective for weight loss; the weight loss reported for each medicine is based on patients taking a licensed maintenance dose.

Orlistat has two dose strengths available in the UK. Access to each depends on patient eligibility and how much clinician monitoring is required. Happen only offers the lower dose, 60 mg.

Not always. While many people follow a monthly dose increase with Wegovy and Mounjaro, others stay on the same dose for longer to let their body adjust. The clinician guides this based on how you're feeling and whether you're experiencing side effects.

If your side effects are more than expected or aren't manageable, let the clinician know. You may be kept on your current dose a bit longer, or even have it reduced temporarily.

If you are taking Orlistat, you take the same dose throughout your treatment.

Some people notice a difference within the first month, but for others it takes longer. Clinical trials show that patients on Wegovy (semaglutide) can lose up to 15% of their body weight after 68 weeks (1), those on Mounjaro (tirzepatide) may lose up to 20% in 36 weeks (2), and those on Orlistat may lose up to 10% in 6 months (3), alongside lifestyle changes including a reduced-calorie diet and more physical activity.

If you haven't lost at least 5% of your weight after six months on Wegovy or Mounjaro, or three months on Orlistat, the clinician will talk with you about next steps. The key is consistency: taking your medicine as prescribed, and making changes to your diet and activity levels.

If you're unsure about your progress, whether that's not losing weight or losing too much, the clinician is here to support you.

1. (1) Garvey WT, Batterham RL, Bhatta M, et al. Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial. Nat Med. 2022;28(10):2083-2091.
2. (2) Aronne LJ, Sattar N, Horn DB, et al. Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial. JAMA. 2024;331(1):38-48.
3. (3) Orlistat 60 mg Summary of Product Characteristics: https://www.medicines.org.uk/emc/product/6533/smpc

With Wegovy and Mounjaro it depends on your goals and how you're doing. These medicines are designed for long-term use to help with lasting weight loss, not as a quick fix.

Once your rate of weight loss has stabilised or you've reached your target weight, the clinician will discuss what's next, keeping your best interests in mind, whether that's to continue, adjust or stop your treatment.

With Orlistat, treatment should not last longer than six months.

When you reach your target weight, the clinician will check in with you. Together, you'll decide whether to continue on a maintenance dose or step away from the medicine.

Although some people start to lose weight within a month of starting treatment, not everyone loses weight at the same pace. If you haven't lost at least 5% of your body weight within six months of taking Wegovy or Mounjaro (or three months of taking Orlistat), the clinician will help you understand why, and explore whether a different approach might work better.

Make sure to take your medicine as prescribed and stick with the lifestyle changes that support your treatment, such as a reduced-calorie diet and more physical activity.

Taking a break is sometimes necessary, but if you miss two doses or more of Wegovy or Mounjaro, you may need to restart the medicine from the lowest dose.

These medicines work best when taken consistently; they are designed to be taken long-term without breaks. If breaks are frequent or needed regularly, the clinician can help decide whether continuing treatment is the right choice for you.

Orlistat is also designed for consistent daily use, but a dose can be skipped if you miss a meal or eat a meal containing no fat.

Let us know if you're planning time away or have any concerns. We're here to support you.

Stomach and digestive (gastrointestinal) side effects are quite common with weight loss medicines, especially when your dose increases (with Wegovy and Mounjaro) or when you first start treatment (with Orlistat). These usually settle with time and can often be eased by changing what and how you eat, or with some over-the-counter medicines.

With Wegovy (semaglutide), very common side effects (affecting more than 1 in 10 people) include headaches, vomiting, diarrhoea, constipation, nausea, bloating, fatigue and weakness.

With Mounjaro (tirzepatide), the most common side effects (affecting more than 1 in 10 people) include vomiting, diarrhoea, constipation and nausea.

With Orlistat, the most common side effects (affecting more than 1 in 10 people) include oily spotting, wind with discharge, an urgent need to open your bowels, fatty or oily stools, oily evacuation, wind and soft stools.

For a complete list of side effects, including less common and rare ones, check the Patient Information Leaflet provided with your medicine.

If you get side effects, tell us in your monthly check-in or contact our support team. Email [email protected] or call 0333 004 0020 (Monday to Friday, 09:30 to 18:30). We reply to emails on the next working day. The team looks at every report and refers anything serious to a clinician. If you're worried, contact NHS 111, or 999 in an emergency.

Many side effects improve with time, but small changes to your diet and routine can make a big difference.

For nausea or mild stomach discomfort, eat smaller, more frequent meals. Choose plain foods with a good balance of protein, avoid fatty meals and eat slowly. Staying hydrated is also key.

If you have very little appetite, try setting reminders to eat and focus on balanced nutrition. Eating whenever you feel hungry, even outside usual mealtimes, can help. Keeping a food diary may also be useful.

If you're feeling bloated, aim for smaller meals, chew slowly and avoid fizzy drinks. Take small sips of water through the day.

For headaches, drink plenty of water, reduce screen time and take breaks outdoors. Resting or napping may also help.

If you have diarrhoea, stay hydrated and avoid caffeine. Eat light meals slowly, reduce fatty foods and insoluble fibre, and consider adding probiotics to your diet.

If you're constipated, drink more water, stay active and make sure you're getting enough fibre through balanced meals.

For side effects associated with Orlistat, try reducing the amount of fat in your diet.

If you ever need urgent medical help for a life-threatening problem, call 999 or go to your nearest A&E. For fast, non-emergency advice, call 111.

No. Don't use other weight-loss medicines alongside your treatment, including over-the-counter products and supplements, as they may interact.

Treatment works best alongside changes to diet and activity.

Mounjaro is injected once a week into your upper arms, tummy (at least 3–5cm away from your belly button), or the front of your thighs. Each time you inject, switch up your injection site slightly (by at least 3cm) to avoid irritation.

• Wash and thoroughly dry your hands before injecting.
• Let your pen come to room temperature before use. You should take it out of the refrigerator about 30 minutes before use.
• Always check the solution in the pen is clear and colourless, and that the pen is in good condition with no damage or leaks. Make sure the expiry date hasn’t passed.
• Choose an injection site on your upper arm, tummy, or the front of a thigh, avoiding scars, moles, or any skin irritation.
• Pull the cap off the pen and set it aside, then take a new needle, remove its protective cap, and screw it onto the pen by twisting it clockwise until securely attached.
• Remove the outer needle cap and set it aside, then remove the inner needle cap and dispose of it safely.
• Turn the dose selector to the first line (‘flow check’) and then point the needle up and press the dose button until it hits 0. You should see a small drop of medication at the tip.
• Turn the dose selector until 1 appears in the dose window, indicating that 1 dose is ready.
• Hold the pen at a 90-degree angle to your skin at your chosen injection site. Press the pen firmly against your skin, and then press and hold the dose selector until it reaches 0.
• Once the full dose has been injected, hold the pen to your skin for a few more seconds, then remove it.
• Carefully place the outer needle cap back on and unscrew the needle from the pen. Dispose of the used needle in a sharps disposal bin. It’s important to never reuse needles.

Be sure to avoid rubbing the injection site, covering it with a plaster if needed, and store any unused pens in your refrigerator, being careful to avoid freezing them.

If you experience issues with using your pen, please refer to the FAQ on this topic.

Below are a few issues patients new to injecting sometimes experience. Don’t worry - as you get the hang of it, injecting will become easier over time.

If the plunger doesn’t seem to be pushing down, do not try to force it, as this may damage the pen. If the plunger feels as if it may be stuck, there may be an issue with the needle. You should try the following:

• Inspect both ends of the needle, ensuring they’re straight and not have been broken or bent. If the needle is bent or broken, make sure that it isn’t stuck in the orange bung. Replace with a new needle if needed and try again.
• Ensure that the needle is properly attached. You should leave only the inner lid on the pen - if the outer protective lid is still in place, you may not be able to properly attach the needle. Twist the needle on as tightly as possible.

Attaching an entirely new needle may help to resolve the issue. Be sure to attach the new needle tightly and properly and avoid bending or damaging it.

If the bung on your pen is swollen and no medication is coming out, it may be that the bung has not been properly punctured by the needle and too much pressure has been applied to the pen. If this is the case, do not try to force medication from the pen, and instead let it sit for a few minutes. Then:

• Unwind the pen back to its original state.
• Allow at least a few hours for the bung to deflate.
• If the bung is not able to deflate on its own, or it explodes, then it is likely you have damaged the pen and you should contact us before proceeding further.

If the pen still appears to have medication but seems jammed (i.e. the pen isn’t turning), this may be because there truly is no medication left or only a partial dose remains. You should note that the pen typically should have some liquid remaining inside even after all doses have been administered; this is intentional, residual liquid not intended for injection. The pen is designed to stop working after the required number of uses. If the plunger has reached the third line on the pen, this indicates that all doses have been used.

If you have not completed all your required doses and there should be a dose left, it’s possible that the remaining dose is partial if you lost some medication during a previous dose or mistook the priming liquid for a dose.

In all instances, be sure to handle the pen gently and never apply too much pressure, as this can damage it. You must also be sure to store the pen properly, with its cap, at an appropriate temperature, removing used needles immediately after injecting and only attaching a new needle when you are getting ready to inject. You should prime the pen before each use.

If you have tried to troubleshoot as above and are still having issues, contact our Patient Support Team at [email protected].

Like many weight loss medications, Mounjaro (tirzepatide) can cause gastrointestinal (GI) side effects, especially during dose increases.

The most common side effects (seen in around 1 in 10 people) include:

• Nausea
• Vomiting
• Diarrhoea
• Constipation

These side effects often improve with time and can be managed with small adjustments to your diet and lifestyle. For a full list, including less common side effects, refer to the Patient Information Leaflet.

No. Mounjaro (tirzepatide) is not recommended if you are pregnant, breastfeeding, or trying to conceive.

If you’re sexually active, you should use contraception while taking Mounjaro. It may reduce the effectiveness of oral contraceptives (like a birth control pill), so speak to your GP about switching to another method, such as an implant or barrier method like condoms.

If you become pregnant while on Mounjaro, stop taking it immediately and contact your GP as soon as possible.

You can drink alcohol in moderation while taking Mounjaro (tirzepatide), but it's best to be cautious. Alcohol may worsen side effects like nausea and can make weight loss more difficult.

If you choose to drink, try to keep it occasional and within recommended limits

In some areas, Mounjaro (tirzepatide) may be available on the NHS for the treatment of obesity. You can speak to your GP to see if it’s an option for you.

Yes — you can purchase Mounjaro (tirzepatide) privately from a licensed UK pharmacy if it has been prescribed by a registered clinician or a private GP.

Before using it, keep your Mounjaro (tirzepatide) pen in the fridge between 2°C and 8°C. Do not freeze it. Once opened, you can store the pen at room temperature or continue refrigerating it — just make sure it stays away from heat and sunlight.

After your first injection, use the remaining doses within 30 days. If you are taking the medication as prescribed, you should finish the medication within this timeframe.

Always keep the cap on when the pen is not in use.

You can inject Mounjaro (tirzepatide) at any time of day — just be consistent and pick the same day each week.

Some people prefer to inject at night or outside of mealtimes to help reduce side effects like nausea. Find what works best for your routine.

Used needles should be placed in a sharps bin straight after use. Never throw them in household waste.

When your sharps bin is full, take it to a pharmacy or contact your local council for proper disposal. Used pens should also be returned to a pharmacy for safe disposal.

Yes, you can travel with your Mounjaro (tirzepatide) pen — just keep it safe and at the right temperature.

Before first use, keep it refrigerated. After opening, you can carry it at room temperature. Always avoid direct sunlight or freezing conditions.

When flying, carry it in your hand luggage with the original packaging and label to help at security or customs. By having it in your hand luggage when travelling via plane, you’ll also be sure it can avoid freezing temperatures.

Wegovy (semaglutide) is injected once a week into the upper arm, abdomen (staying 3–5cm away from the belly button), or the front of the thigh. Change the injection site slightly (3cm) each time to avoid irritation.

• Thoroughly wash and dry your hands.
• Before use, let the pen warm to room temperature. Take the pen out of the refrigerator about 30 minutes before injecting and check the pen’s expiry date and that it isn’t damaged or leaking. The solution in the pen should be clear and colourless, and free from particles.
• Choose an injection site on your upper arm, abdomen, or front of thigh, avoiding areas with scars, moles, or skin irritation.
• Pull the cap off the pen and set aside, then take a new needle and remove its protective cap. Screw the needle onto the pen by twisting clockwise until securely attached. Remove the outer needle cap and set aside, and then remove the inner needle cap and dispose of it safely.
• Turn the dose selector to 'flow check' (2 dots and a line). Point the needle up and press the dose button until it hits 0. You should see a small drop of medication at the tip.
• Turn the dose selector until the correct dose appears in the window (note that at this point you cant turn the dial anymore). Hold the pen at a 90-degree angle to your skin. Push the pen firmly against your skin. Press on the dose selector until it reaches 0.
• Once the full dose has been injected hold the pen for a few seconds on the skin before removing.
• Carefully place the outer needle cap back on and unscrew the needle from the pen. Dispose of the needle in a sharps disposal container. Do not reuse the needle.

Always store unused pens in the fridge — but never freeze them. Put a plaster over the injection site if you think you may rub at it.

If you experience issues with using your pen, please refer to the FAQ on this topic.

Below are a few issues patients new to injecting sometimes experience. Don’t worry - as you get the hang of it, injecting will become easier over time.

If liquid is not coming out through the needle, ensure that the needle is properly attached and that it isn’t bent or damaged. Ensure it is tightly screwed on and that the outer and inner needle caps are both removed. If necessary, try attaching a new needle.

If the dose button seems stiff or is hard to push, ensure that the needle is attached tightly and correctly. If needed, try attaching a new needle. The dose button is intended to be pushed slowly.

If you notice that there is liquid left in your pen, and you’ve already taken 4 doses, don’t worry - this is normal. There is extra liquid in the pen that is there to provide enough to carry out a flow check (or priming) before using your pen.

In all instances, be sure to handle the pen gently and never apply too much pressure, as this can damage it. You must also be sure to store the pen properly, with its cap, at an appropriate temperature, removing used needles immediately after injecting and only attaching a new needle when you are getting ready to inject.

If you have tried to troubleshoot as above and are still having issues, contact our Patient Support Team at [email protected].

Wegovy (semaglutide) may cause gastrointestinal (GI) side effects, especially as your dose increases.

Common side effects (seen in around 1 in 10 people) include:

• Nausea
• Vomiting
• Diarrhoea
• Constipation
• Headaches
• Bloating
• Fatigue
• Weakness

Most of these side effects are mild and tend to ease over time.

For more details, including less common and rare side effects, please refer to the Patient Information Leaflet.

No. Wegovy (semaglutide) is not recommended if you are pregnant, trying to conceive, or breastfeeding.

If you are sexually active, use contraception while taking Wegovy. If you take the pill, speak to your GP — Wegovy may reduce the effectiveness of oral contraceptives, so you should consider switching birth control methods, such as using an implant or condoms.

If you want to become pregnant, stop Wegovy at least two months before trying to conceive. If you become pregnant while on Wegovy, stop taking it immediately and contact your GP right away.

You can drink alcohol in moderation while taking Wegovy (semaglutide), but it's best to be cautious. Alcohol may worsen side effects like nausea and can make weight loss more difficult.

If you choose to drink, try to keep it occasional and within recommended limits.

Wegovy (semaglutide) may be available through the NHS in certain areas for the treatment of obesity. Speak to your GP to find out if you’re eligible.

Yes. Wegovy (semaglutide) can be purchased privately from a licensed UK pharmacy, but you’ll need a valid prescription from a registered clinician or private GP.

Before first use, store Wegovy pens in the fridge between 2°C and 8°C — do not freeze them. If a pen is frozen, it is no longer safe to use.

After using the pen for the first time, you can then continue refrigerating the pen or keep it at room temperature, away from heat and sunlight. Use the remaining doses within 6 weeks of the first injection (which shouldn’t be a problem, so long as you are taking the medication as prescribed).

Always keep the pen capped when not in use.

Any time of day is fine — just stick to the same day and time each week.

Some people prefer to inject before bed or away from meals, especially if they’re prone to nausea. Find a routine that works for you.

After each injection, dispose of the used needle in a sharps bin. Don’t put needles in your household waste.

When your sharps bin is full, you can take it to most pharmacies or contact your local council for safe disposal of clinical waste.

Yes, just plan ahead. Before using the pen, keep it refrigerated. After your first dose, you can travel with it at room temperature — just avoid freezing or overheating.

Carry your pen in your hand luggage and keep it in its original packaging with the label. Carrying it in your hand luggage when flying will help ensure it doesn’t freeze.

Orlistat comes as a capsule, taken up to three times a day with meals. It works in the stomach and intestines by blocking the enzymes (lipases) that break down the fat you eat, which stops about a third of that fat from being absorbed into the body. The undigested fat passes out in your stools, which creates a calorie deficit that helps with weight loss.

Happen only offers the non-prescription dose of Orlistat (60 mg), so no prescription is needed. It is a pharmacy medicine, which means it must be obtained from a pharmacy and used under supervision.

Take one Orlistat capsule with each main meal, up to three times a day. You can take it immediately before, during, or up to one hour after the meal. Swallow it with water.

If you miss a meal, or your meal contains no fat, skip that dose of Orlistat.

Very common side effects of Orlistat (affecting more than 1 in 10 people) include oily spotting, wind with discharge, an urgent need to open your bowels, fatty or oily stools, oily evacuation, wind and soft stools.

For most people these happen when they first start treatment and often subside over time. Reducing the fat in your diet can reduce them.

No. Orlistat is not recommended if you are pregnant or breastfeeding.

If you use an oral contraceptive, it's recommended that you also use an additional barrier method (for example condoms), because severe diarrhoea could cause the oral contraceptive to fail.

You can drink alcohol in moderation while taking Orlistat, but it's best to be cautious. Alcohol may worsen side effects and can make weight loss more difficult. If you choose to drink, keep it occasional and within recommended limits.

Orlistat is suitable for many people who meet the established criteria, but it should be used under the guidance and supervision of a clinician.

The clinician reviews your consultation to decide whether Orlistat is suitable and likely to be effective for you. Ongoing check-ins keep that under review for as long as you're treated with us. For more details, see the Patient Information Leaflet provided with your medicine.

In some areas, Orlistat may be available on the NHS for the treatment of obesity. Speak to your GP to see if it's an option for you.

Yes. You can buy Orlistat 60 mg privately from a licensed UK pharmacy following a pharmacy consultation.

Store Orlistat in its original container, securely closed, at room temperature in a dry place away from heat, moisture and direct light. Keep it out of the sight and reach of children and pets.

Yes. Carry your medicine in your hand luggage, in its original packaging with the label. Keeping it in your hand luggage helps it stay at room temperature.

Wegovy tablets contain semaglutide, a medicine that mimics a naturally occurring hormone called GLP-1. It helps to regulate your appetite, slows the emptying of your stomach and increases feelings of fullness.

This can help you feel fuller for longer, reduce hunger and cravings, eat smaller portions more naturally, and support long-term weight loss when combined with healthy lifestyle changes.

Yes. Wegovy tablets are a prescription-only medicine and are only suitable for certain patients.

Before it can be prescribed, you complete an online consultation and clinical assessment. One of our experienced clinicians reviews your information to decide whether Wegovy tablets are suitable for you.

Wegovy tablets are taken once every day. For the tablet to work effectively, take it first thing in the morning, on an empty stomach after fasting for at least 8 hours, swallowed whole with about 120 ml of water, and at least 30 minutes before eating, drinking anything else or taking other medicines.

Taking the tablet correctly each day matters, because semaglutide is absorbed differently when taken by mouth.

If you miss a dose of Wegovy tablets, skip the missed dose completely and take your next dose at the usual time the following day.

Don't take two tablets together, take an extra tablet later in the day, or double your dose the next morning. Because Wegovy tablets need to be taken under specific conditions, extra doses may increase side effects and reduce how well the medicine is absorbed.

Some of the most common side effects include nausea, vomiting, diarrhoea, constipation, stomach discomfort or indigestion, bloating or wind, headache, dizziness, tiredness or fatigue, heartburn and reduced appetite.

For most people these side effects are mild and often improve as the body adjusts to treatment.

No. Wegovy tablets should not be used if you are pregnant, trying to become pregnant or breastfeeding.

Speak with your clinician if you become pregnant or plan to start a family while on treatment.

You can drink alcohol in moderation while taking Wegovy tablets. Alcohol may worsen some side effects, such as nausea, dizziness and stomach upset, and can make weight management harder.

If you choose to drink, keep it moderate and stay well hydrated.

Wegovy tablets are suitable for many people who meet the prescribing criteria. As with all prescription medicines, they should only be used under clinical supervision.

Our clinicians review your consultation to decide whether treatment is suitable for you. Ongoing check-ins keep your treatment under review throughout your weight loss journey. For more information, see the Patient Information Leaflet supplied with your medicine.

Wegovy injections are currently available on the NHS for some eligible patients in certain areas of the UK.

Whether Wegovy tablets become available on the NHS depends on future NHS commissioning decisions and local eligibility criteria. Speak with your GP if you'd like to discuss NHS treatment options.

Yes. Following their approval in the UK, Wegovy tablets can be prescribed privately by appropriately qualified healthcare professionals after a clinical assessment confirms they are suitable for you.

Store Wegovy tablets at room temperature in their original packaging, in a dry place away from excessive heat, moisture and direct sunlight. Keep all medicines out of the sight and reach of children and pets.

Yes. Unlike injectable weight loss medicines, Wegovy tablets do not need refrigerating. Carry them in their original packaging when travelling, in your hand luggage where possible.

Its tablet form makes it a convenient option if you travel regularly or would rather not store injectable medicine while away from home.

In many cases, yes. If you're currently taking Wegovy injections, our clinical team can assess whether switching to Wegovy tablets is appropriate for you.

Depending on your previous dose and how well you tolerated treatment, your clinician may recommend a different starting dose when you move to the tablet.

Wegovy tablets come in four dose strengths: 1.5 mg once daily in month 1, 4 mg in month 2, 9 mg in month 3, and 25 mg once daily from month 4 onwards (the maintenance dose).

Your dose is increased gradually to let your body adjust and help minimise side effects. Our clinical team monitors your progress and supports you throughout. Some patients need an individual plan depending on their medical history, previous treatment and how well they tolerate the medicine.

Foundayo contains the active ingredient orforglipron.

It works by influencing the way your body regulates appetite, which can help you feel satisfied with less food and support weight loss when used alongside a reduced-calorie diet and increased physical activity.

Yes. Foundayo is a prescription-only medicine.

Before treatment can be prescribed, you'll need to complete an online consultation and clinical assessment. A qualified clinician will review your information to decide whether Foundayo is suitable for you.

Foundayo is available in six strengths:

• 0.8mg
• 2.5mg
• 5.5mg
• 9mg
• 14.5mg
• 17.2mg

The usual starting dose is 0.8mg once daily for 30 days, followed by 2.5mg once daily. Your clinician may then gradually increase your dose depending on your treatment response and how well you tolerate the medication.

The maximum dose is 17.2mg once daily.

Foundayo is taken as one tablet once a day.

Foundayo can be taken:

• At any time of day
• With or without food

Swallow the tablet whole. Do not break, crush or chew it.

Try to build taking your tablet into your daily routine to help you remember it each day.

If you forget your Foundayo tablet, take it as soon as you remember.

Do not take more than one dose in the same day and do not take a double dose to make up for one you've missed.

Very common side effects, affecting more than 1 in 10 people, include:

• Nausea
• Constipation
• Diarrhoea
• Vomiting
• Indigestion
• Abdominal pain

Nausea, diarrhoea and vomiting are most common when first starting treatment and decrease over time for most patients.

Other common side effects can include headache, dizziness, bloating, burping, heartburn, gas, gallstones, hair loss and tiredness.

Speak to your clinical team if you're concerned about any side effects or if they're difficult to manage.

No. Foundayo should not be used during pregnancy or while breastfeeding.

If you're planning a pregnancy, speak to your clinician. Foundayo should be stopped at least 3 weeks before trying to become pregnant.

It may.

Foundayo may reduce the effectiveness of oral hormonal contraception.

If you use an oral contraceptive, you should consider using an additional barrier method, such as condoms, or switching to a non-oral method of contraception for:

• 30 days after starting Foundayo
• 30 days after each increase in dose

Speak to your clinician if you're unsure which contraceptive method is appropriate for you.

Foundayo has been authorised by the MHRA for weight management in appropriate adults.

Like all prescription medicines, it isn't suitable for everyone. Your consultation will be reviewed by a qualified clinician before treatment is prescribed, and ongoing check-ins help us monitor your progress throughout treatment.

Foundayo is also currently subject to additional monitoring in the UK.

Always read the Patient Information Leaflet supplied with your medication.

Foundayo is licensed for weight management alongside a reduced-calorie diet and increased physical activity in adults who initially have:

• A BMI of 30 or above

or

• A BMI of at least 27 but below 30, together with at least one weight-related health condition.

Your BMI alone doesn't determine whether treatment is suitable. Your clinician will review your complete medical information before making a prescribing decision.

Potentially. Foundayo is a different medication and there is no simple dose-for-dose conversion from Mounjaro, Wegovy injections or Wegovy tablets.

If you're already receiving weight management treatment, your clinician will consider your current medication, dose, treatment history, response and tolerability when deciding whether Foundayo is an appropriate option for you.

Never switch between treatments or change your dose without clinical guidance.

No.

Foundayo should be kept in its original packaging to protect it from light and kept out of the sight and reach of children.

Yes.

As Foundayo doesn't require refrigeration, it can be convenient to take when travelling.

Keep your medication in its original labelled packaging and carry it securely with you when travelling.

No.

Both medicines are manufactured by Eli Lilly, but they're different treatments.

Foundayo contains orforglipron and is taken once daily.

Mounjaro contains tirzepatide and is administered as a weekly injection.

Your clinician can determine which treatment options may be appropriate for you.

No.

Both are oral treatments used for weight management, but they contain different active ingredients and have different dosing and administration requirements.

Foundayo contains orforglipron and can be taken at any time of day, with or without food.

Wegovy contains semaglutide and has specific instructions around when and how the tablet should be taken.

Your clinician can help determine which treatment may be appropriate for you.

We aim to deliver within 72 hours of your order being approved. Monday to Wednesday, orders approved before 12pm are dispatched the next working day, and orders approved after 12pm are dispatched the working day after that. On Thursday the cut-off is 6pm: orders approved by 6pm on Thursday are dispatched on Friday.

We don't dispatch at weekends, so orders approved after 6pm on Thursday, on Friday or at the weekend are dispatched on Monday. An order approved on a Friday morning can sometimes be dispatched the same day, but this isn't guaranteed, especially when we're busy.

Please make sure you're at home to receive any temperature-controlled medicine, as it needs to be kept between 2°C and 8°C. The packaging keeps your medicine cool for up to 48 hours, which is usually enough for one or two delivery attempts by the courier.

To help you receive your parcel on time, you'll get notifications when it's been dispatched from the pharmacy and a tracking link from the courier.

Delivered by DPD. You'll get a tracking link to choose a delivery time. DPD parcels can't be left in a safe place: someone must be in to give the driver the PIN. DPD sends you a PIN to give the driver. The driver can't hand your parcel to anyone who doesn't have the PIN.

Royal Mail Tracked 24. You can choose a safe place, redirect or collect using the tracking link. If you choose a safe place, you take on the risk: we are not responsible for parcels left in a safe place. Whichever option you choose, it's always best to be at home to receive your parcel.

We keep you updated at every step, with emails when your treatment has been approved and when it's been dispatched by the pharmacy. You'll also receive an email telling you when it will be delivered, with a tracking link from the courier.

If the clinician needs more information, they'll contact you directly.

If you haven't received any emails from us, check your spam or junk folders, as it's important that you're kept up to date with your order.

No. Your medicine is dispensed by a UK pharmacy and can only be delivered to UK addresses, and the clinicians and pharmacy are in the UK, so treatment can only be provided to people in the UK.

If you're going abroad for a while and need extra medicine, contact us in advance at [email protected] so we can arrange a consultation. It may be possible to get an additional supply before you leave. Please allow enough time for the consultation and delivery.

Yes. Provided you complete the regular check-ins, and the clinician decides that continuing treatment is suitable and effective for you, the service works on a subscription, so you always have your medicine when you need it.

Payment for your first order is taken at checkout, once you've completed your online consultation and may be eligible. If it's decided that treatment isn't suitable for you, you'll receive a full refund. Your second payment is taken 21 days after your first order is delivered, and later payments 28 days after each delivery.

If you're not approved for another supply, for example because the clinician decides you're no longer eligible, your most recent payment is refunded and you won't be charged again.

Once an order has been approved and dispensed, it can't be cancelled or refunded, so it's important to pause or cancel in your account before your next payment date if you don't want your next order.

You can always see the date and amount of your next payment by logging in to your account.

Before your current medicine runs out, you'll receive an email with a short check-in form to complete. Once a clinician has reviewed your answers and decided which dose is best for you, the pharmacy sends out your next order so it arrives before you need it. You're charged automatically for this order using the payment method on your account.

The check-in is an important part of your treatment plan: it helps us make sure your medicine stays suitable and effective for you. We can't send your next medicine until the check-in has been completed and reviewed. In some cases a clinician may contact you for more information before they can complete their review.

With Wegovy (semaglutide) and Mounjaro (tirzepatide), the amount you're charged is based on the dose you've said you'd like. That dose is subject to review by a clinician who, depending on your progress, any side effects and other clinical considerations, may decide a different dose is more suitable for you.

In that case, before your order is dispatched, the difference is refunded to you (if a lower dose is prescribed) or the extra amount is charged (if a higher dose is prescribed).

If you don't ask for a dose change, or you haven't completed your check-in before your order is created, you're charged the same as your previous dose. Once you complete your check-in, the charge is adjusted as above in line with the updated dose.

With Orlistat, we only offer one dose (60 mg).

Yes. In your account you can move your next payment and order up to 21 days later or 7 days earlier.

Pausing or moving your payment date can affect the next dose you receive.

Log in to your account and choose Pause. This stops your payments and puts future orders on hold straight away, for up to 3 months. Nothing is charged while you're paused.

If you miss more than two doses of Wegovy or Mounjaro, you'll probably need to start again at the lowest dose, which may slow your progress. When you restart, you complete a short check-in. Your card is charged once our team has checked it, before the clinician reviews it. If it's decided that treatment isn't suitable for you, you'll receive a full refund.

Any order that has already been approved and dispensed can't be refunded. If you have medicine you no longer need, take it to a local pharmacy to be disposed of properly.

Pausing or moving your payment date can affect the next dose you receive.

Yes, but the pause only applies to future orders. Once your current order has been approved and dispensed, we can't cancel or refund it. This is in line with the rules on selling prescription medicines at a distance; see our terms of sale for details.

To pause future orders, log in to your account, go to Your deliveries and choose Pause. It takes effect at once.

You can cancel at any time from your account. There's no minimum term. Cancelling takes effect at once: future payments stop straight away.

If your order has already been approved and dispensed by the pharmacy, we can't cancel or refund that order.

Report it in your account with a photo, for example an item that is damaged or missing, and our team will reply within one working day.

You can raise anything with a clinician in your regular check-ins. If you need to reach them sooner, contact our support team. Email [email protected] or call 0333 004 0020 (Monday to Friday, 09:30 to 18:30). We reply to emails on the next working day. If you're worried, contact NHS 111, or 999 in an emergency.

If you need your next order early, or an additional supply because you're travelling or have lost your medicine, get in touch with the team at [email protected].